2021

Vessoni AT, Zhang T, Quinet A, Jeong HC, Munroe M, Wood M, Tedone E, Vindigni A, Shay JW, Greenberg RA, Batista LF. Telomere erosion in human pluripotent stem cells leads to ATR-mediated mitotic catastrophe. Journal of Cell Biology (2021). Pubmed

2020

Munroe M, Niero EL, Fok WC, Vessoni AT, Jeong HC, Brenner KA and Batista LF. telomere dysfunction activates p53 and represses HNF4a expression leading to impaired human hepatocyte development and function. Hepatology (2020). Pubmed

Shukla S, Jeong HC, Sturgeon M, Parker R and Batista LF. Chemical inhibition of PAPD5/7 rescues telomerase function and hematopoiesis in dyskeratosis congenita. Blood Advances (2020). Pubmed

Vessoni AT, Filippi-Chiela EC, Lenz G and Batista LF. Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence. Oncogene (2020). Pubmed

Quinet A, Tirman S, Jackson J, Šviković S, Lemaçon D, Carvajal-Maldonado D, González-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LF, Méndez J, Sale JE and Vindigni A. PRIMPOL-mediated adaptative response suppresses replication fork reversal in BRCA-deficient cells. Molecular Cell (2020). Pubmed

2019 – 2015

Fok WC, Shukla S, Vessoni AT, Brenner KA, Parker R, Sturgeon CM and Batista LF. Posttranscriptional modulation of TERC by PAPD5 inhibition rescues hematopoietic development in dyskeratosis congenita. Blood (2019). Pubmed

Brestoff JR, Vessoni AT, Brenner KA, et al. Acute graft-versus-host disease following lung transplantation in a patient with a novel TERT mutation. Thorax (2018). Pubmed

Fok WC, Niero EL, Dege C, Brenner KA, Sturgeon CM and Batista LF. p53 mediates failure of human definitive hematopoiesis in dyskeratosis congenita. Stem Cell Reports (2017). Pubmed

Fok WC and Batista LF. Stressed ends: telomere attrition in chronic diseases. Rev Bras Hematology (2017). Pubmed

Huh CJ, Zhang B, Victor MB, Dahiya S, Batista LF, Horvath S and Yoo AS. Maintenance of Age in Human Neurons Generated by MicroRNA-based Neuronal Conversion of Fibroblasts. eLIFE (2016). Pubmed

2014 – 2009

Kareta MS, Gorges LL, Hafeez S, Benayoun BA, Marro S, Zmoos AF, Cecchini MJ, Spacek D, Batista LF, O’Brien M, Ng YH, Ang CE, Vaka D, Artandi SE, Dick FA, Brunet A, Sage J and Wernig M. Inhibition of Pluripotency Networks by the Rb Tumor Suppressor Restricts Reprogramming and Tumorigenesis. Cell Stem Cell (2014). Pubmed

Batista  LF  and  Artandi  SE.  Understanding  telomere  diseases  through  analysis  of patient-derived iPS cells. Current Opinion in Genetics & Development (2013). Pubmed

Zhong FL, Batista LF, Freund A, Pech MF, Venteicher AS, Artandi SE. TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends.  Cell (2012). Pubmed

Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera R and Artandi SE.  Telomere  shortening  and  loss  of  self-renewal  in  dyskeratosis  congenita  induced pluripotent stem cells.  Nature (2011). Pubmed

Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Dahlborg EJ, Ramirez CL, Reyon D, Batista LF, Artandi SE, Wernig M & Joung JK. In Situ Genetic Correction  of the Sickle Cell Anemia Mutation in Human Induced Pluripotent Stem Cells Using Engineered Zinc Finger Nucleases.  Stem Cells (2011). Pubmed

Batista  LF  and  Artandi  SE. Telomere  uncapping,  chromosomes,  and  carcinomas. Cancer Cell (2009). Pubmed

Saffi J, Agnoletto MH, Guecheva TN, Batista LF, Carvalho H, Henriques JA, Stary A, Menck CF,  Sarasin  A.  Effect  of  the  anti-neoplastic  drug  doxorubicin  on  XPD-mutated  DNA repair-deficient human cells.  DNA Repair (2010). Pubmed

Arruda-Neto  JD, Friedberg  EC, Bittencourt-Oliveira  MC, Segreto  HR, Moron MM, Maria DA, Batista  LF, Schenberg  AC.  The role played  by endogenous  and exogenous  electric fields in DNA signaling and repair.  DNA Repair (2010). Pubmed

Batista LF, Kaina B and Menck CFM. How DNA lesions are turned into powerful killing structures: insights on UV-induced apoptosis.  Mutation Research – Reviews (2009). Pubmed

Batista LF, Roos WP, Kaina B and Menck CFM. p53 mutant human glioma cells are sensitive to UV-C  induced  apoptosis  due  to  impaired  CPD  removal.   Molecular Cancer Research (2009). Pubmed

2008 – 2001

Batista LF, Roos WP, Christmann M, Menck CFM and Kaina B. Differential sensitivity of malignant glioma cells to methylating and chloroethylating anticancer drugs: p53 determines the switch by regulating xpc, ddb2 and DNA double-strand breaks.  Cancer Research (2007). Pubmed

Roos WP, Batista LF, Naumman SC, Wick W, Weller M, Menck CFM and Kaina B. Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6- methylguanine.  Oncogene (2007). Pubmed

Batista  LF,  Chiganças  V,  Brummati  G,  Amarante-Mendes   GP  and  Menck  CFM. Involvement of DNA replication in ultraviolet-induced apoptosis of mammalian cells.  Apoptosis (2006). Pubmed

Chiganças V, Batista LF, Brummati G, Amarante-Mentes GP, Yasui A and Menck CFM. Photorepair of RNA polymerase arrest and apoptosis after ultraviolet irradiation in normal and XPB deficient rodent cells.  Cell Death & Differentiation (2002). Pubmed